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Doxy-PEP guide

Doxy-PEP online in Virginia and West Virginia

This guide is for adults who want a standing doxycycline prescription to take after condomless sex to reduce STI risk — not for treating an active infection, and not for HIV or pregnancy prevention.

Start online

Start a $59 online review for Doxy-PEP.

Doxy-PEP is a single dose of doxycycline taken within 72 hours after condomless sex to lower the risk of chlamydia, syphilis, and gonorrhea. The strongest evidence is in men who have sex with men and transgender women who have had an STI in the past year, but it can be a shared-decision option for others at high ongoing risk. It does not prevent HIV or pregnancy.

If treatment is appropriate, your physician can send a non-controlled prescription to your pharmacy and provide portal instructions for the next step.

Quick facts

  • You must be physically in Virginia and West Virginia at the time of request
  • Starts at $59
  • No insurance needed
  • No app download
  • Physician review around the clock
  • Non-controlled prescriptions can be sent to your pharmacy when appropriate
  • A work or school note can be included when medically appropriate
  • Response windows: 24/7, every day

Common symptoms

  • No current symptoms - this is prevention, not treatment
  • Recent or anticipated condomless sex
  • Ongoing high risk for bacterial STIs

May fit online care

  • Adults 18 and older
  • Condomless sex within the last 72 hours, or a request for a standing prescription for future exposures
  • No current STI symptoms
  • Not pregnant, no tetracycline allergy, age 18 or older
  • Willing to complete quarterly STI screening for refills

Look for another care setting

  • Current STI symptoms (discharge, sores, pain, rash) - needs testing and treatment
  • Pregnancy or possible pregnancy
  • A doxycycline or tetracycline allergy
  • Under age 18

What to have ready

  • When your most recent condomless sex was
  • Whether you have any current STI symptoms
  • Medication allergies, especially to doxycycline or tetracyclines
  • Willingness to complete quarterly STI screening

What happens next

Start the request on the website, answer the fit questions, and choose the response window you want. If the concern still fits this service, a physician reviews it and sends a secure update after sign-in. When appropriate, non-controlled prescriptions can be sent to your pharmacy, and a basic work or school note can be included at physician discretion.

Your physician

Every visit is personally reviewed by Ankur Fadia, MD — board-certified, cardiology-fellowship-trained, and Alpha Omega Alpha. Recognized with the Act Fast Award for the fastest physician stroke-treatment times (2019–2022) and as the most efficient, highest-rated physician in the HCA LewisGale Alleghany emergency department (2018). Licensed in Virginia and West Virginia — your care is never handed off.

Does doxy-PEP prevent HIV or pregnancy?

No. Doxy-PEP only targets bacterial STIs — chlamydia, syphilis, and (to a lesser extent) gonorrhea. It does not prevent HIV or pregnancy, so continue using condoms and consider HIV PrEP if you're at ongoing risk.

Who benefits most from doxy-PEP?

The strongest evidence is in men who have sex with men and transgender women who have had a bacterial STI in the past 12 months. Others at high ongoing STI risk may still be a reasonable fit through shared decision-making.

How often can I use it?

Up to 10 doses a month, taking one 200 mg dose as soon as possible and within 72 hours after condomless sex. Refills require a quarterly STI screen.